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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • VU 0361737 EI2904

    VU 0361737是选择性mGlu4阳性变构的调节剂（positive allosteric modulator）。

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  • VU 0357017 hydrochloride EI2900

    VU 0357017 hydrochloride是M1受体阳性变构的调节剂（positive allosteric modulator）。

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  • VU 0357121 EI2901

    VU 0357121是mGlu5阳性变构的调节剂（positive allosteric modulator）。

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  • VU 0360172 hydrochloride EI2902

    VU 0360172 hydrochloride是mGlu5阳性变构的调节剂（positive allosteric modulator）。

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  • VU 0255035 EI2898

    VU 0255035是高选择性muscarinic M1受体的拮抗剂。

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