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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Suvorexant EY2834

    Suvorexant是OX受体拮抗剂，对OX1和OX2受体的Ki分别为0.55 nM和0.35 nM。

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  • Boceprevir EY2833

    Boceprevir是HCV蛋白酶抑制剂，Ki为14 nM。

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  • γDGG EI3038

    γDGG是广谱的glutamate的受体拮抗剂。

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  • α，β-Methyleneadenosine 5'-triphosphate trisodium salt EI3021

    α，β-Methyleneadenosine 5'-triphosphate trisodium salt是P2的激动剂。

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  • ZM 226600 EI3010

    ZM 226600是Kir6 (KATP) 的通道开启剂（channel opener）。

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