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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • VUF 10460 EI2917

    VUF 10460是选择性 H4 激动剂。

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  • VU 0409106 EI2908

    VU 0409106是活性选择性mGlu5阴性变构的调节剂（negative allosteric modulator）。

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  • VU 0422288 EI2909

    VU 0422288是选择性group III mGlu的阳性变构的调节剂（positive allosteric modulator）。

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  • VU 0483605 EI2912

    VU 0483605是mGlu1阳性变构的调节剂（positive allosteric modulator）。

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  • VU 0364439 EI2905

    VU 0364439是mGlu4阳性变构的调节剂（positive allosteric modulator）。

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