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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • VU 1545 EI2913

    VU 1545是mGlu5阳性变构的调节剂（positive allosteric modulator）。

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  • VU 29 EI2914

    VU 29是活性mGlu5变构增强剂（allosteric potentiator）。

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  • VU 591 hydrochloride EI2916

    VU 591 hydrochloride是选择性 Kir1.1 (ROMK) 抑制剂。

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  • VUF 10460 EI2917

    VUF 10460是选择性 H4 激动剂。

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  • VU 0409106 EI2908

    VU 0409106是活性选择性mGlu5阴性变构的调节剂（negative allosteric modulator）。

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