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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • XAP 044 EI2959

    XAP 044是活性的，选择性 mGlu7 拮抗剂。

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  • XE 991 dihydrochloride EI2960

    XE 991 dihydrochloride是活性的， 选择性 KV7 (KCNQ) 通道阻断剂， 可以阻断M电流。

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  • Y-26763 EI2964

    Y-26763是Kir6 (KATP)通道开启剂（channel opener）。

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  • Y-27152 EI2965

    Y-27152是是Kir6 (KATP)通道开启剂Y-26763的前药， 口服生物活性保留，在体内有长效的降压活性。。

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  • Xanomeline oxalate EI2957

    Xanomeline oxalate是选择性M1激动剂。

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