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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    EGF816 is a third-generation covalent EGFR inhibitor that has potent inhibitory activity against activating and resistant T790M mutants with low IC50 in various cellular assays.

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    HM-71224 is an EGFR tyrosine kinase inhibitor.

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    Favipiravir是一种有效的选择性RNA-dependent RNA polymerase抑制剂。

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