In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
Acetazolamide是一种碳酸酐酶(CA)有效抑制剂。
MoreDEL-22379抑制ERK二聚化, IC50=0.5 μM。
MoreLX-4211是SGLT1/2抑制剂,是抗糖尿病剂。
MoreH3B-6527是一个有选择性的FGFR4抑制剂,有抗肿瘤的性质。
MoreBardoxolone(RTA 402)是抗氧化炎症调节剂(AIM)的先导化合物。
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