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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    (-)-U-50488 hydrochloride是标准的选择性 κ 激动剂。 是 (±)-U-50488的更有活性的对映体。

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  • (-)-Pentazocine EI0059

    (-)-Pentazocine是κ-激动剂，镇痛活性。

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  • (-)-Cannabidiol EI0054

    (-)-Cannabidiol是Natural cannabinoid， GPR55 拮抗剂， 弱效 CB1 拮抗剂， CB2反相激动剂，AMT的抑制剂。

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  • (-)-Bicuculline methochloride EI0053

    (-)-Bicuculline methochloride是水溶性 GABAA 拮抗剂。

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  • (-)-Bicuculline methiodide EI0052

    (-)-Bicuculline methiodide是Water-soluble GABAA 拮抗剂。

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