In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
3-Methyl-GABA是GABA amino-transferase的激动剂。
More3-MATIDA是活性的, 选择性 mGlu1 拮抗剂。
More3-Cyano-7-ethoxycoumarin是Fluorescent cytochrome P450 substrate。
More2-ThioUTP tetrasodium salt是活性的,选择性 P2Y2 激动剂。
More2-Pyridylethylamine dihydrochloride是H1 受体 激动剂。
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