In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
4-DAMP是Muscarinic M3 拮抗剂。
More4-Aminopyridine是非选择性voltage-dependent K+通道阻断剂。
More4,4-Pentamethylenepiperidine hydrochloride是M2 proton 通道阻断剂。
More3-Methyl-GABA是GABA amino-transferase的激动剂。
More3-MATIDA是活性的, 选择性 mGlu1 拮抗剂。
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