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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Bay 36-7620 EI0532

    Bay 36-7620是非竞争性 mGlu1 拮抗剂有反向激动剂活性。

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  • AZD 9272 EI0521

    AZD 9272是活性的，选择性 mGlu5 拮抗剂， 可透过血脑屏障。

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  • AZD 7762 hydrochloride EI0520

    AZD 7762 hydrochloride是Chk1，Chk2的活性选择性 ATP-竞争性抑制剂。

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  • AZD 3988 EI0518

    AZD 3988是活性的，选择性 DGAT-1 抑制剂。

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  • AZD 2066 EI0516

    AZD 2066是mGlu5 拮抗剂， 口服有效，。

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