COX
Cyclooxygenase (COX) is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. Pharmaceutical inhibition of COX can provide relief from the symptoms of inflammation and pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The two isozymes found in human are called COX-1 and COX-2 in the medical literature.
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Piroxicam是非选择性COX抑制剂，IC50为6 mM。
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Valdecoxib是一种强有效和选择性的COX-2抑制剂，IC50为5nM.
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Rutaecarpine是从 Evodia rutaecarpa和相关草药中分离的indolopyridoquinazolinone生物碱。
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Ibuprofen 是一种抗炎类抑制剂，作用于COX-1和COX-2，IC50分别为13 μM和370 μM。
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Lornoxicam是高活性COX-1和COX-2抑制剂，IC50分别为5nM和8nM，是一个新型非甾体抗炎化合物。
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