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COX


Cyclooxygenase (COX) is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. Pharmaceutical inhibition of COX can provide relief from the symptoms of inflammation and pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The two isozymes found in human are called COX-1 and COX-2 in the medical literature.

  • NS-398 EY2015

    NS-398是一种COX-2抑制剂，抑制作用呈浓度依赖性。100μM NS-398不影响COX-1活性， 而抑制COX-2活性（IC50: 3.8 μM）。

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  • Bufexamac EY1842

    Bufexamac是COX环氧酶抑制剂，靶点是IFN-α， EC50 为8.9 μM, 具有抗炎活性。

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  • Nimesulide EY1706

    Nimesulide是COX-2选择性抑制剂和非甾体抗炎化合物。

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  • Rofecoxib EY1673

    Rofecoxib是COX-2抑制剂，IC50为18nM。

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  • Niflumic acid EY1387

    Niflumic acid是钙离子激活的氯离子通道阻断剂，可作用于风湿性关节炎。

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