Dopamine Receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 receptors are members of the D2-like family.
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(+)-UH 232 maleate是D2 自主受体拮抗剂。 也是D3 部分激动剂。
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(+)-PD 128907 hydrochloride是D3 激动剂 (D3 ≥ D2 > D4)。
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(+)-AJ 76 hydrochloride是拮抗剂， 优先作用于 D2-样自主受体。
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(-)-Quinpirole hydrochloride是选择性 D2-样激动剂。
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Zotepine是5-HT2A/D2 拮抗剂， 非典型的抗精神病药物（antipsychotic）。
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(+)-UH 232 maleate是D2 自主受体拮抗剂。 也是D3 部分激动剂。
More
-
(+)-PD 128907 hydrochloride是D3 激动剂 (D3 ≥ D2 > D4)。
More
-
(+)-AJ 76 hydrochloride是拮抗剂， 优先作用于 D2-样自主受体。
More
-
(-)-Quinpirole hydrochloride是选择性 D2-样激动剂。
More
-
Zotepine是5-HT2A/D2 拮抗剂， 非典型的抗精神病药物（antipsychotic）。
More
