Dopamine Receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 receptors are members of the D2-like family.
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2-CMDO是D2样拮抗剂。 展现部分 D4 选择性。
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(RS)-(±)-Sulpiride是标准选择性 D2-样拮抗剂。
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(R)-(-)-Apomorphine hydrochloride是Dopamine 激动剂， 无亚型的选择性。
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(±)-MDMA hydrochloride是5-HT，dopamine uptake inhibitor， hallucinogenic activity。
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(±)-McN 5652是活性的， 口服活性的5-HT 吸收抑制剂。体外也能抑制 noradrenalin，dopamine的吸收。
More
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2-CMDO是D2样拮抗剂。 展现部分 D4 选择性。
More
-
(RS)-(±)-Sulpiride是标准选择性 D2-样拮抗剂。
More
-
(R)-(-)-Apomorphine hydrochloride是Dopamine 激动剂， 无亚型的选择性。
More
-
(±)-MDMA hydrochloride是5-HT，dopamine uptake inhibitor， hallucinogenic activity。
More
-
(±)-McN 5652是活性的， 口服活性的5-HT 吸收抑制剂。体外也能抑制 noradrenalin，dopamine的吸收。
More
