Dopamine Receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 receptors are members of the D2-like family.
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Nafadotride是高活性,竞争性的preferential D3 拮抗剂。（Ki = 0.52, 5, and 269 nM for human cloned D3, D2 and D4 receptors respectively.）
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Mesulergine hydrochloride是5-HT2A 和5-HT2C 拮抗剂。 也是dopamine 受体部分激动剂。
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Melperone hydrochloride是5-HT2A/D2 受体拮抗剂， 安定精神作用。
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Mephedrone hydrochloride是抑制 synaptosomal dopamine，5-HT uptake inhibitor（摄取抑制剂）。
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LE 300是活性的，选择性 dopamine D1 拮抗剂。
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Nafadotride是高活性,竞争性的preferential D3 拮抗剂。（Ki = 0.52, 5, and 269 nM for human cloned D3, D2 and D4 receptors respectively.）
More
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Mesulergine hydrochloride是5-HT2A 和5-HT2C 拮抗剂。 也是dopamine 受体部分激动剂。
More
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Melperone hydrochloride是5-HT2A/D2 受体拮抗剂， 安定精神作用。
More
-
Mephedrone hydrochloride是抑制 synaptosomal dopamine，5-HT uptake inhibitor（摄取抑制剂）。
More
-
LE 300是活性的，选择性 dopamine D1 拮抗剂。
More
