Adrenergic Receptor
The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline). Epinephrine (adrenaline) reacts with both α- and β-adrenoreceptors, causing vasoconstriction and vasodilation, respectively. High levels of circulating epinephrine cause vasoconstriction. At lower levels of circulating epinephrine, β-adrenoreceptor stimulation dominates, producing vasodilation followed by decrease of peripheral vascular resistance.
Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes dilating the pupils, increasing heart rate, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle.
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Xylazine hydrochloride (盐酸甲苯噻嗪) 是α2肾上腺素受体激动剂。
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(R)-(-)-Phenylephrine 盐酸盐是α1-肾上腺受体激动剂。
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Brimonidine Tartrate 是一种高度选择性 α-adrenergic receptor 拮抗剂，其对α2A adrenoreceptor的 EC50 为 0.45 nM ,并用于治疗开角型青光眼或高眼压症。
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(S)-Timolol Maleate是非选择性β-肾上腺素受体拮抗剂，对β1和β2受体亚型的Ki分别为1.97和2.0 nM。
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Yohimbine hydrochloride 是α-2肾上腺素能受体抑制剂，阻断突触前或突触后的α-2肾上腺素能受体，引起去甲肾上腺素和多巴胺的释放。
More
-
Xylazine hydrochloride (盐酸甲苯噻嗪) 是α2肾上腺素受体激动剂。
More
-
(R)-(-)-Phenylephrine 盐酸盐是α1-肾上腺受体激动剂。
More
-
Brimonidine Tartrate 是一种高度选择性 α-adrenergic receptor 拮抗剂，其对α2A adrenoreceptor的 EC50 为 0.45 nM ,并用于治疗开角型青光眼或高眼压症。
More
-
(S)-Timolol Maleate是非选择性β-肾上腺素受体拮抗剂，对β1和β2受体亚型的Ki分别为1.97和2.0 nM。
More
-
Yohimbine hydrochloride 是α-2肾上腺素能受体抑制剂，阻断突触前或突触后的α-2肾上腺素能受体，引起去甲肾上腺素和多巴胺的释放。
More
