Adrenergic Receptor
The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline). Epinephrine (adrenaline) reacts with both α- and β-adrenoreceptors, causing vasoconstriction and vasodilation, respectively. High levels of circulating epinephrine cause vasoconstriction. At lower levels of circulating epinephrine, β-adrenoreceptor stimulation dominates, producing vasodilation followed by decrease of peripheral vascular resistance.
Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes dilating the pupils, increasing heart rate, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle.
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3-MPPI是α1 配体。
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2-PMDQ是活性的， 选择性 α1 拮抗剂。
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2-MPMDQ是活性的， 选择性 α1 拮抗剂。也是σ2 配体。
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(S)-(+)-Niguldipine hydrochloride是α1 拮抗剂， L-type Ca2+ 通道阻断剂。
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(S)-(-)-Propranolol hydrochloride是β 拮抗剂。Propranolol活性更好的的对映体之一。
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3-MPPI是α1 配体。
More
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2-PMDQ是活性的， 选择性 α1 拮抗剂。
More
-
2-MPMDQ是活性的， 选择性 α1 拮抗剂。也是σ2 配体。
More
-
(S)-(+)-Niguldipine hydrochloride是α1 拮抗剂， L-type Ca2+ 通道阻断剂。
More
-
(S)-(-)-Propranolol hydrochloride是β 拮抗剂。Propranolol活性更好的的对映体之一。
More
