HIV Protease
HIV (The human immunodeficiency virus) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells.[4] HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including pyroptosis of abortively infected T cells, apoptosis of uninfected bystander cells,[6] direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells.[7] When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.
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Indinavir is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors.
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Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.
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Saquinavir mesylate是HIV 蛋白酶抑制剂。
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NBD 556是CD4 mimetic，NBD 556可以阻断 HIV-1 进入细胞。。
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BMS-626529是HIV-1 gp120抑制剂，能阻止其与CD4+ T细胞的结合。
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