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Clofarabine is a potent HIV-1 inhibitor in both activated CD4+ T cells and macrophages. Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase
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Tamoxifen is a selective estrogen receptor (ER) modulator. Tamoxifen-induced apoptosis was associated with inhibition of cancerous inhibitor of protein phosphatase 2A (CIP2A) and phospho-Akt (p-Akt) in a dose-dependent manner.
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Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. Dienogest is a hybrid progestin possessing characteristics both of 19-nortestosterone derivatives and progesterone derivatives.
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Nepafenac is a potent NSAID that rapidly penetrates the eye following topical ocular administration. In the eye, nepafenac is converted to amfenac, which has unique time-dependent inhibitory properties for COX-1 and COX-2.
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Artemisinin, a potent antimalarial, can be used to cure multidrug-resistant Plasmodium falciparum infections.
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