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Integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
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Firategrast是口服有效的整合素α4β1/α4β7小分子拮抗剂。
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FAK Inhibitor 14 is a selective focal adhesion kinase (FAK) inhibitor, it prevents FAK autophosphorylation at Y397 (IC50 = 1μM).
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ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B, and minimal activity against a panel of other kinases tested.
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