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IWR-1-endo, an active endo form of IWR-1, is a small molecule inhibitor for Wnt/β-catenin signaling via the inhibition of tankyrase. IWR-1-endo是一种Wnt通路抑制剂，IC50为180 nM，诱导Axin2蛋白水平，且促进β-catenin磷酸化。
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FH535, a dual small-molecule inhibitor of Wnt/β-catenin signaling pathway and the peroxisome proliferator-activated receptor (PPAR), shows potent inhibition of various cancers. FH535能双重抑制Wnt/beta-catenin和PPAR信号通路。
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WY-14643 (Pirinixic Acid), a moderate dual PPARα/γ activator, inhibits neuroinflammation and oxidative stress, and also possesses antidepressive activities. WY-14643 (Pirinixic Acid)是一种有效的过氧化物酶体增殖子和PPARα激活剂，EC50为1.5 μM。
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Entinostat (MS-27-275, MS-275, SNDX-275) an orally class I histone deacetylase (HDAC)-specific inhibitor, is currently in clinical trials.
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Tamoxifen citrate, a selective non-steroidal estrogen receptor antagonist, was approved by FDA as a drug that is utilized in the treatment of estrogen receptor–positive breast cancer. Tamoxifen Citrate是一种雌激素受体拮抗剂，与雌激素竞争性结合。
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