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  • BLU-554 EY1726

    BLU-554是一种有效的、高度选择性的、具有口服活性的FGFR4抑制剂，IC50为5 nM。

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  • BI-847325 EY2849

    BI-847325是一种口服具有生物活性的选择性的双重MEK/Aurora kinase抑制剂，对人类MEK2和AK-C的IC50值分别为4和15 nM。

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  • GLPG0187 EY2848

    GLPG0187是广谱的integrin受体拮抗剂，具有抗肿瘤活性；抑制αvβ1-integrin的IC50值为1.3 nM。

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  • ASP8273 EY2847

    ASP8273 is a small molecule, irreversible TKI inhibitor that inhibits the kinase activity of EGFR mutations including T790M, with limited activity against EGFR wild-type NSCLC. In the in vitro enzymatic and cell-based assays, ASP8273 were evaluated against EGFR mutantsand WT EGFR.

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  • EGF-816 EY2846

    EGF816 is a third-generation covalent EGFR inhibitor that has potent inhibitory activity against activating and resistant T790M mutants with low IC50 in various cellular assays.

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