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  • D-I03 EY5007

    D-I03 is a selective inhibitor of RAD52 with a Kd value of 25.8 µM. D-I03 inhibits ssDNA annealing via RAD52 and D-loop formation, with IC50 values of 5 µM and 8 µM, respectively.

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  • SCR7 pyrazine EY5006

    SCR7 pyrazine is an inhibitor of DNA ligase IV that blocks non-homologous end joining (NHEJ) in a ligase IV‑dependent manner. SCR7 pyrazine enhances the efficiency of Cas9‑mediated homology‑directed repair (HDR). SCR7 pyrazine induces apoptosis and exhibits anticancer activity.

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  • Mirin EY5004

    Mirin is a potent inhibitor of the Mre11–Rad50–Nbs1 (MRN) complex and can inhibit Mre11-associated exonuclease activity. Mirin suppresses MRN-dependent activation of ATM.

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  • AZD-7648 EY5003

    AZD‑7648 是一种高选择性、口服有效的 DNA‑PK 抑制剂，IC50 值为 0.6 nM。AZD‑7648 可诱导细胞凋亡（apoptosis），并具有抗肿瘤活性。

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  • ART558 EY5001

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