Topoisomerase
Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork. If left unabated, this torsion would eventually stop the ability of DNA or RNA polymerases involved in these processes to continue down the DNA strand.Topoisomerases are isomerase enzymes that act on the topology of DNA.Bacterial topoisomerase and human topoisomerase proceed via the same mechanism for replication and transcription.
-
Idarubicin盐酸盐是蒽环类抗生素和DNA拓扑异构酶II（topo II）抑制剂。
More
-
Doxorubicin (Adriamycin)是一种抗生素类试剂，能够抑制DNA拓扑异构酶II，且诱导DNA损伤和凋亡。
More
-
Natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Exhibits GPBA receptor agonist activity (EC50 = 1.04 μM).
More
-
(S)-10-Hydroxycamptothecin 是临床治疗肝癌的有效试剂。
More
-
Gatifloxacin是第四代氟喹诺酮类抗生素，能抑制细菌的DNA旋转酶和拓扑异构酶IV。
More
