Topoisomerase
Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork. If left unabated, this torsion would eventually stop the ability of DNA or RNA polymerases involved in these processes to continue down the DNA strand.Topoisomerases are isomerase enzymes that act on the topology of DNA.Bacterial topoisomerase and human topoisomerase proceed via the same mechanism for replication and transcription.
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Daunorubicin Hydrochloride 能抑制DNA和RNA合成，对DNA合成的Ki为0.02 μM。
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Ciprofloxacin是氟喹诺酮类广谱抗生素。
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SN-38是CPT-11的一种活性代谢物，抑制DNA topoisomerase I（DNA拓扑异构酶I） ，IC50为1 μM，抑制DNA合成，且造成频繁的DNA单链断裂。
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Irinotecan(CPT-11)能通过抑制拓扑异构酶1阻止DNA的解旋。
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Camptothecin是一种特异性的DNA拓扑异构酶I (Topo I)抑制剂，IC50为0.68 μM。
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