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  • Niclosamide EY0323

    Niclosamide, an FDA approved anthelmintic drug, is an inhibitor of Wnt co-receptor LRP6 and suppresses both the Wnt/β-catenin pathways and the mTOR/STAT3 pathway. Niclosamide抑制DNA复制，抑制STAT，IC50为0.7 μM。

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  • Epothilone B EY0324

    Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.

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  • GDC-0994 EY0328

    GDC-0994 is a potent, orally available ERK inhibitor with IC50 1.1 nM and 0.3 nM, respectively.

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  • GSK3787 EY0336

    GSK3787 is a selective and irreversible PPARβ/δ antagonist with good pharmacokinetic properties. GSK3787是不可逆的PPARδ选择性拮抗剂，pIC50为6.6，对hPPARα和hPPARγ无亲和力。

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  • A66 EY0337

    A66是一种有效的，特异性的p110α抑制剂，IC50为32 nM，作用于p110α比作用于其他I型PI3K亚型选择性高100倍以上。

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