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LY3039478 is a novel and potent Notch inhibitor.
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Tocilizumab is an anti-interleukin-6 receptor (IL-6R) monoclonal antibody, currently approved for the treatment of systemic juvenile idiopathic arthritis (sJIA) and rheumatoid arthritis.
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Trastuzumab, an anti- ERBB2 (HER2 or HER-2/neu) humanized monoclonal antibody, is used to treat “HER2-positive” tumors.
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Pembrolizumab (MK-3475, lambrolizumab), a highly selective humanized monoclonal immunoglobulin G4 (IgG4)/kappa isotype antibody that blocks the interaction between PD-1 and its ligands, has demonstrated antitumor activity in multiple tumor types.
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Nivolumab (BMS-936558, MDX-1106, ONO-4538), an anti-PD-1 monoclonal antibody, has been reported to have anti- tumor effects and approved for the treatment of unresectable or metastatic melanoma in treatment-refractory patients.
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