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Ranibizumab, a humanized, affinity-matured VEGF antibody fragment that neutralizes all isoforms of VEGF, is approved for use in ophthalmology.
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Rituximab, a monoclonal antibody directed at CD20 positive B-lymphocytes, is the first-line treatment of acquired thrombotic thrombocytopenic purpura.
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Muromonab CD3 (OKT3), the murine anti-CD3 monoclonal antibody of the IgG-2a class, used as a powerful immunosuppressive agent in solid organ transplantation and the first-line treatment of acute allograft rejection.
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Natalizumab is a humanized monoclonal antibody against α4 integrins highly effective in relapsing-remitting multiple sclerosis (MS).
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Efalizumab, a recombinant humanized monoclonal IgG1 antibody directed against a subunit (CD11a) of leukocyte function-associated antigen-1 (LFA-1), inhibits the T cell activation, migration and adhesion to keratinocytes.
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